Long non-coding RNA LASSIE regulates shear stress sensing and endothelial barrier function.
Laura Stanicek , Noelia Lozano-Vidal, Diewertje Ilse Bink, Aukie Hooglugt, Wenjie Yao, Ilka Wittig, Jos van Rijssel, Jaap Diederik van Buul , Anke van Bergen, Alina Klems, Anne Sophie Ramms, Ferdinand Le Noble, Patrick Hofmann, Robert Szulcek, ShengPeng Wang, Stefan Offermanns, Meryem Seda Ercanoglu, Hyouk-Bum Kwon, Didier Stainier, Stephan Huveneers, Leo Kurian, Stefanie Dimmeler, Reinier Abraham Boon.
Commun Biol., 2020 May 26;3(1):265. DOI: 10.1038/s42003-020-0987-0
Key findings
- Fluid flow controls endothelial expression of several long non-coding RNAs (lncRNA), including the highly induced lncRNA LASSIE.
- LASSIE is required for proper endothelial barrier function and for endothelial alignment in the direction of flow.
- LASSIE physically interacts with adherens junction proteins and with the cytoskeletal protein nestin.
- Loss of LASSIE results in weakening of the cytoskeletal attachment to adherens junctions.
