Postdoc in innate immunity and vascular biology

We are looking for a driven and motivated researcher at the postdoctoral level to join Oskar Eriksson’s research group at the Department of Immunology, Genetics and Pathology, located at the Rudbeck Laboratory in Uppsala. The research in the group is very translational and aims to better understand how the innate immune system and the complement system contribute to disease development. The main aim of this postdoctoral project is to investigate endothelial cell-specific expression of complement factors and its significance for cardiovascular disease.

The current project will investigate endothelial cell-specific expression of complement factors and their function in endothelial activation and blood clotting. The project will use a combination of wet lab methods and analysis of publicly available RNAseq and proteomics datasets. It will also be possible to verify experimental findings in clinical materials.
Tasks in the project will include cultivation of endothelial cell lines and endothelial cells from various human tissues, as well as mapping and phenotypic characterization of expressed complement factors. Cell analysis methods such as flow cytometry and fluorescence microscopy will be used. The project will also include recombinant protein expression and purification of proteins and antibodies from plasma. An important aim of the project will be to establish a cell-based screening model for complement and coagulation activation on the endothelial cell surface. As a postdoctoral fellow you will also be expected to assist in the supervision of master students and doctoral students.

The research group has several national and international collaborations that can be developed further as part of the project. There is also the possibility to develop the project according to one’s own skills and interest.

The applicant should have a PhD in medicine or biology relevant to the project. The degree needs to be obtained by the time of the decision of employment. Those who have obtained a PhD degree three years prior to the application deadline are primarily considered for the employment.

Please contact Oskar Eriksson (oskar.eriksson@igp.uu.se, with your interest or send in your application using the following link: https://www.uu.se/en/about-uu/join-us/jobs-and-vacancies/job-details?query=793660