Postdoctoral or PhD position in zebrafish models of vascular anomalies

The Seyfried lab invites applications for centrally-funded Postdoc (E13/100%) and PhD student (E-13/65%) positions. Our research focusses on molecular mechanisms involved in vascular anomalies. We use genetic disease models in the zebrafish embryo. This will allow us to characterize pathological signaling events that are involved in vascular malformations. We would like to understand: What are the pathological signals that cause the abnormal morphogenesis of blood vessels? To what extent does the molecular identity of different vascular beds modify the progression towards a pathological state? How do endothelial cell behaviors change in response to pathological signaling? Can we use pharmacological screens to identify substances that suppress pathological vascular signaling?
Our team participates in the Leducq Transatlantic Network of Excellence “ReVAMP” (Recalibrating Vascular Anomalies by Pharmacological Intervention) and we tightly collaborate with clinical researchers, basic research teams, and with pharmaceutical/ biotechnology companies. Our lab is embedded within the Potsdam/Berlin biomedical research arena with many collaboration partners on campus and within the vicinity. Our group consists of an interactive, dynamic, and international research team.
Training will involve:
State-of-the-art technologies including next-generation sequencing CRISPR-Cas9 genome editing to generate zebrafish models of human pathologies
Pharmacological suppression screens
Confocal and light sheet microscopy
Working in a large and modern zebrafish facility
Please, send your application including your current CV, research interests, and contact information for three references by December 31st, 2024 to Prof. Dr. Salim Seyfried (salim.seyfried@uni-potsdam.de).