Research Associate in Advanced Organ-on-chip technology and Vascular Biology

Anna RandiByAnna Randi

Research Associate in Advanced Organ-on-chip technology and Vascular Biology

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Website LabAnna Imperial College London

We are seeking a Post-Doctoral Research Associate to develop a gut-on-chip angiogenesis model and study von Willebrand Factor (VWF) regulation of angiogenesis in the gut. The research follows the seminal discovery by the Randi team that VWF regulates angiogenesis (Starke et al, Blood 2011; Ishihara et al, Blood 2019), which shed light on how vascular abnormalities contribute to gastrointestinal (GI) bleeding in patients with Von Willebrand Disease (VWD). In this project we aim to develop a microfluidic gut-on-chip model to study the influence of the gut microenvironment on angiogenesis, to interrogate molecular pathways and test new therapies for GI bleeding in VWD.

This project brings together Prof. Randi’s expertise on VWD and endothelial cell biology/angiogenesis in London, UK with bioengineering expertise in Prof. Rasponi’s lab in Milan, Italy. Prof. Randi is Head of Vascular Science, National Heart and Lung Institute (NHLI) at Imperial College London. She leads a team of basic and clinician scientists addressing aspects of endothelial biology ( Prof. Rasponi leads the Microfluidics and biomimetic Microsystems Laboratory (MiMic Lab at the Politecnico University in Milan, Italy, a team at the cutting-edge of the organ-on-chip technology. For the first ~4 months, you will join Prof. Rasponi’s bioengineering team in Milan to develop a gut-on-a-chip model of organotypic angiogenesis. You will then transfer the model to Prof. Randi’s lab in London, UK, where you will work with colleagues who will provide cell lines and tools to be tested in the gut-on-chip model. The project combines bioengineering, molecular/cell biology and biochemistry methods. You will be supported by and collaborate with two international, multidisciplinary team to deliver an exciting new precision medicine approach to validate candidate new therapies for GI bleeding in VWD.

Full-time and Fixed term contract for 30 months; MRC-funded

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Anna Randi

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