PhD position at European Center for Angioscience

Mahak SinghalByMahak Singhal

PhD position at European Center for Angioscience

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Website Heidelberg University, Medical Faculty Mannheim, European Center for Angioscience

Project title: Interrogating the impact of circadian changes in blood vessels on organ health.

Summary: Earth’s rotation imposes a day-night cycle, which underlies the necessity for an endogenous circadian clock to adapt organ physiology to environmental changes. Within an organ, blood vessel-lining endothelial cells (EC) not only form a critical interface between the circulation and the local tissue milieu but also secrete paracrine signals to exert an instructive role on steady-state organ function. Yet, circadian changes in vascular molecular circuits and their influence on diurnal oscillations in organ function remain elusive. Located at the European Center for Angioscience, Singhal lab focuses on the role of blood vessels in sustaining circadian rhythm in organ physiology and their gatekeeper role in the development and progression of different pathologies such as cancer and inflammation. For more details, visit us @ www.singhallab.de

We are seeking motivated team players with a strong scientific foundation in biological sciences and/or medicine to join a dynamic team headed by Dr. Mahak Singhal (mahak.singhal@medma.uni-heidelberg.de) within the European Center of Angioscience, Heidelberg. We pursue curiosity-driven research, integrating a data-intensive approach with preclinical disease models and state-of-the-art analytical techniques. We offer an international & family-friendly environment. The position is available ASAP and will be initially financed for three years.

Please apply via the HBIGS portal – https://my-hbigs.uni-heidelberg.de/site/index.php?a=VXUyYmJHRXR4aHhRVk9LcTdmWThnbGNOZUtBV0JTUmIvS0VDL1BkSnlpeUxCMU1vc003QkNHaTl0UXE4V2xGVCs1WXdRWGJIdDFYOFVNT1lKSGd2Wi91V01FRjJ4N2RWL0ZERG1DUjRMMmY4bFJrWExTM1JZTzU5ZmtNSG5iWms%3D

Methods that will be used:
Wet lab: Preclinical animal experiments, including tissue injury and regeneration models. We employ standard cell culture and molecular biology assays, flow cytometric analysis, and FACS-based cell sorting of multiorgan EC, IF & IHC tissue staining. Experience with handling small animals and flow cytometry would be a plus but not mandatory.
Dry lab: We pursue multiomic experiments focusing on bulk and single-cell RNAseq and proteomics. While we have a dedicated bioinformatics scientist in the lab who undertakes much of the data analysis, it is advised that all wet lab scientists also perform complementary pathway analysis of data corresponding to their datasets. We will train you in various in-silico tools. 🙂

Cooperation partners: Our interdisciplinary research relies on numerous collaboration partners across the life science campus of Heidelberg University, covering ECAS Manheim, DKFZ Heidelberg, Uniklinikum Heidelberg, and Uniklinikum Mannheim.

Personal qualifications: We are looking for a highly motivated student with a solid scientific foundation and enthusiasm to learn more. We expect you to be proficient in English and a team player.

References:

1. Singhal M#, et. al.: Temporal multi-omics identifies LRG1 as a vascular niche instructor of metastatic colonization. Sci Transl Med, 13:eabe6805, 2021 (# Co-corresponding authors).
–> Featured as a cover story in the September issue of Science Translational Medicine.
2. Gengenbacher N*, Singhal M*, et. al.: Timed Ang2-targeted therapy identifies the Angiopoietin-Tie pathway as key regulator of fatal lymphogenous metastasis. Cancer Discov, 11:424-445, 2021 (*equally contributing first authors).
3. Singhal M, et. al.: Preclinical validation of a novel metastasis-inhibiting Tie1 function-blocking antibody. EMBO Mol Med, 12:e11164, 2020.
–> Accompanied by an editorial by Prof. Robert Kerbel. EMBO Mol Med, 12:e12355, 2020
4. Singhal M, et. al.: Endothelial cell fitness dictates the source of regenerating liver vasculature. J Exp Med 215:2497-508, 2018.
–> Accompanied by an editorial by Prof. Luisa Iruela-Arispe. J Exp Med 215:2480-482, 2018

To apply for this job please visit my-hbigs.uni-heidelberg.de.

About the author

Mahak Singhal

Mahak Singhal subscriber