Trichoplein binds PCM1 and controls endothelial cell function by regulating autophagy
Andrea Martello, Angela Lauriola, David Mellis, Elisa Parish, John C Dawson, Lisa Imrie, Martina Vidmar, Noor Gammoh, Tijana Mitić, Mairi Brittan, Nicholas L Mills, Neil O Carragher, Domenico D’Arca, Andrea Caporali.
EMBO Rep. 2020 Jul 3;21(7):e48192. doi: 10.15252/embr.201948192.
Key findings
1.The interaction of TCHP with PCM1 regulates basal autophagy through controlling GABARAP stability.
2.Loss of TCHP results in impaired autophagy, the accumulation of SQSTM1/p62 and endothelial dysfunction.
3.Reduced TCHP and high SQSTM1/p62 levels are detected in primary endothelial cells from patients with coronary artery disease.
4.Accumulation of SQSTM1/p62 correlates with impaired endothelial function and can be ameliorated by NF‐κB inhibition.
Links to website/social media
https://www.ed.ac.uk/profile/andrea-caporali
Twitter: @EdiUniCIRR; @EdinUniCVS
