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We are looking for an enthusiastic vascular Research Associate with a strong interest in patient- and disease-specific organ/tissue-models. This 3-year post is funded by the British Heart Foundation to investigate the role of Arf signalling in organ-on-a-chip model of pulmonary arterial hypertension (PAH).
PAH is an incurable disease, characterised by high blood pressure in the lung arteries. Activation of Arf GTPases contributes endothelial dysfunction in PAH. This project aims to identify the mechanism of Arf6-dependent changes in membrane receptor trafficking, identify strategies of Arf6 targeting and evaluate the effect of Arf6 activity changes on pulmonary vascular function in vitro, using cellular and translational approaches in a novel microfluidic pre-clinical platform, pulmonary artery-on-a-chip.
Duties and responsibilities
You will join a multidisciplinary team of basic scientists and clinicians working on pathogenesis of pulmonary hypertension. You will help to generate new knowledge on disease aetiology, underlying biochemical pathways and mechanisms. Under the academic mentors’ guidance, you will support the development of a new microfluidic platform for personalised medicine, pulmonary artery-on-a-chip.
The work combines expertise across a range of in vitro techniques, including cell culture, qRT PCR, molecular cloning, immunostaining/histochemistry, luciferase reporter assays, Western blotting, GTP-binding assays, scanning ion conductance microscopy, fluorescence confocal microscopy and image analysis.
You will be expected to submit publications to refereed journals and to attract external research funding.
- PhD in molecular/cell biology or a closely related discipline, or equivalent research, industrial or commercial experience.
- Knowledge of research methods and statistical procedures.
- Practical experience within a research environment and/or publication in relevant and refereed journals.
- Practical experience in a broad range of cell and molecular biology techniques.
- Experience in confocal microscopy imaging techniques.
- Computer literate with a good knowledge of different computer programmes with experience in data presentation and statistical analyses.
Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range £35,477 – £38,566 per annum.
The role is full-time and fixed-term until 31 May 2022.
The College cannot normally apply for a Certificate of Sponsorship for this post under Tier 2 of the UKVI’s Points Based System. Any candidate, who is considering applying for this position and requires sponsorship, must ensure that they are able to obtain permission to work in the UK through an appropriate immigration route.
Should you require any further details on the role please contact Dr Beata Wojciak-Stothard: firstname.lastname@example.org.
For technical issues when applying online please email email@example.com.
The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/
Imperial College is committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment. We are an Athena SWAN Silver award winner, a Stonewall Diversity Champion, a Disability Confident Employer and work in partnership with GIRES to promote respect for trans people.
To apply, visit www.imperial.ac.uk/jobs and search by the job MED01570.