Joint head Vascular Sciences, and Head of the Endothelial Cytoprotection group
Imperial College London
South Kensington Campus, London SW7 2AZ,
Degrees and Diplomas:
BSc (Lond) 1983 First Class Honours – Biochemistry & Immunology London University
MB BS 1986 Honours in Pathology London University
MRCP (UK) 1989
PhD 1996 London University
Current post (2009-2026): Professor of Vascular Rheumatology, National Heart and Lung Institute Imperial College London and Honorary Consultant Physician, Hammersmith Hospital, London.
HEFCE funded. Clinically active – UK Silver national ACCEA award 2016.
Joint head Vascular Sciences, Imperial College, Head of the Endothelial Cytoprotection group
Summary of previous posts:
Reader and Honorary Consultant Physician, Imperial College London 2005 – 2009
Arthritis Research Campaign Senior Clinical Fellow 2000 – 2005
Arthritis Research Campaign Clinician Scientist Fellow 1997 – 2000
Senior Registrar Rheumatology/Medicine Hammersmith & Ealing Hospitals 1995 – 1997
MRC Training Fellow – Royal Postgraduate Medical School 1992 – 1995
Registrar in Rheumatology – Hammersmith Hospital London 1991 – 1992
Registrar in General Medicine – Wexham Park Hospital, Slough 1990 – 1991
Recent relevant publications
1. FDG Uptake by Prosthetic Arterial Grafts in Large Vessel Vasculitis Is Not Specific for Active Disease. Youngstein T, Tombetti E, Mukherjee J, Barwick TD, Al-Nahhas A, Humphreys E,Nash J, Andrews J, Incerti E, Tombolini E, Salerno A, Sartorelli S, Ramirez GA,Papa M, Sabbadini MG, Gianolli L, De Cobelli F, Fallanca F, Baldissera E,Manfredi AA, Picchio M, Mason JC. JACC Cardiovasc Imaging. 2017 E pub Jan 11.
2. Methotrexate-mediated activation of an AMPK-CREB-dependent pathway: a novel mechanism for vascular protection in chronic systemic inflammation. Thornton CC, Al-Rashed F, Calay D, Birdsey GM, Bauer A, Mylroie H, Morley BJ, Randi AM, Haskard DO, Boyle JJ, Mason JC. Ann Rheum Dis. 2016; 75:439-448.
3. Identification of cyclins A1, E1 and vimentin as downstream targets of heme oxygenase-1 in vascular endothelial growth factor-mediated angiogenesis. Andrea Bauer A, Mylroie H, Thornton CC, Calay D, Birdsey GM, Kiprianos AP, Wilson GK, Soares MP, Yin X, Mayr M, Randi AM, Mason JC. Sci. Rep. 2016: 6, 29417.
4. PKCε-CREB-Nrf2 signaling induces HO-1 in the vascular endothelium and enhances resistance to inflammation and apoptosis. H Mylroie, O Dumont, A Bauer, CC Thornton, J Mackey, D Calay, SS Hamdulay, JR Choo, JJ. Boyle, AM Samarel, AM Randi, PC Evans, JC Mason. Cardiovasc Res. 2015 106:509-19.
5. Synergistic therapeutic vascular cytoprotection against complement-mediated injury induced via a PKCα, AMPK and CREB-dependent pathway. SS Hamdulay, B Wang, D Calay, AP Kiprianos, J Cole, O Dumont, N Dryden, AM Randi, CC Thornton, F Al-Rashed, C Hoong, A Shamsi, Z Liu, VR Holla, JJ Boyle, DO Haskard, JC Mason.
J Immunol 2014: 192:4316-27.
6. An investigational analysis reveals a potential role for neutrophils in GCA disease progression.S Nadkarni, J Dalli, J Hollywood, JC Mason*, B Dasgupta*, M Perretti*. *shared senior author. Circ Res 2014: 114:242-248.
I am delighted and honoured to have been proposed for membership of the EVBO council. I am a rheumatologist and vascular endothelial biologist interested in mechanisms of systemic inflammation. I lead a basic science and clinical research lab, alongside a specialised tertiary referral service for patients suffering from large vessel vasculitis, including Takayasu arteritis and giant cell arteritis.
I have been a member of EVBO since its inception and an enthusiastic supporter ever since. My current research interests include: (i) a basic science programme investigating molecular mechanisms involved in the regulation of vascular endothelial cytoprotection and how these might be therapeutically manipulated, and (ii) clinical research seeking to optimise assessment of arterial injury in the large vessel vasculitides, and understanding the relationship between chronic endothelial dysfunction and accelerated atherosclerosis.
I have recently taken over as joint head of Vascular Sciences at Imperial College London with Professor Anna Randi, and I am joint head of the Imperial Vasculitis Centre with Professor Charles Pusey. I developed and continue to organise the annual Imperial College Endothelial Symposium, now in its 19th year, which aims to provide both a scientific and clinical perspective on the role of the vasculature in disease pathogenesis. The meeting has brought together vascular scientists and clinicians from across Europe. Likewise, I organise regional and national vasculitis meetings. A key aim of these meetings, and for myself on the council if elected, will be to encourage young scientists into vascular research and provide them with support. I hope to contribute to the activities of the EVBO and that my experience might help drive the EVBO forward. In these troubling political times I would be keen to represent the United Kingdom vascular biologists on the EVBO council and to confirm our commitment to European science.