POSTDOCTORAL RESEARCH ASSOCIATE VACANCY; Vascular Science, National Heart and Lung Institute. Salary: £36,800 – £39,800 per annum
Applications are invited for the position of Research Associate, to work in the Endothelial Homeostasis Group led by Prof. Anna Randi, to study the transcriptional and epigenetic drivers of endothelial lineage and regeneration.
The post is funded by a BHF Centre for Vascular Regeneration, a consortium of laboratories which includes Imperial College, Edinburgh and Bristol. The project focuses on blood outgrowth endothelial cells (BOEC), also known as endothelial colony forming cells (ECFC), and aims to define the molecular pathways which confer these cells the proliferative and regenerative advantage compared to differentiated endothelium. Through genome-wide studies of these cells’ transcriptional profile, transcription factors binding and histone modifications (transcriptome, cistrome and epigenome), we aim to identify lineage-specific pathways to be exploited for regenerative medicine approaches.
The laboratory has a strong track record of research on endothelial transcriptional pathways which control vascular development, angiogenesis and homeostasis (see Birdsey et al, Developmental cell 2015; Shah et al, Nature Communications 2017 and Dufton et al, Nature Communications 2017). We also have an interest in BOEC/ECFC as a translational tool to investigate disease (see Starke et al, Blood 2013 and Paschalaki et al, Stem Cell 2013).
The project combines our expertise in these two areas. Genome-wide profiling by RNA seq and ChIP seq will be carried out in BOEC; bioinformatics analysis will identify candidates to be taken forward for validation in in vitro and ex vivo endothelial models. In vivo validation in models of vascular regeneration will be carried out in collaboration with partners within the BHF Centre for Vascular Regeneration and the BHF Cardiovascular Regenerative Medicine Centre, also based at Imperial College London.
We are seeking a highly-motivated scientist to join a collaborative team of research scientists. You should have a PhD in a relevant biological discipline and experience in transcription and epigenetics studies. Some knowledge of bioinformatic analysis of these datasets is essential. Previous experience in cell culture and BOEC/ECFC is desirable. The post will require collaboration with other groups both within and outside the Vascular Sciences department.
The post is full-time fixed-term for 2 years and based at the Hammersmith Campus, located near White City, London.
Further information on the Vascular Sciences Section can be found at: http://www.imperial.ac.uk/nhli/research/cardiovascular/vascular-science/
Informal enquiries may be sent to Prof. Anna Randi (email@example.com)
Closing Date: 5th January 2018 (midnight BST)
How To Apply
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