{"id":720,"date":"2022-05-03T15:43:36","date_gmt":"2022-05-03T15:43:36","guid":{"rendered":"http:\/\/evbo.org\/?page_id=720"},"modified":"2022-05-03T15:57:33","modified_gmt":"2022-05-03T15:57:33","slug":"evbo-publication-highlights-june-2020","status":"publish","type":"page","link":"https:\/\/evbo.org\/index.php\/evbo-publication-highlights-june-2020\/","title":{"rendered":"EVBO publication highlights \u2013 June 2020 winner"},"content":{"rendered":"\n<h3 class=\"wp-block-heading\"><strong>Long non-coding RNA LASSIE regulates shear stress sensing and endothelial barrier function.<\/strong><\/h3>\n\n\n\n<p>Laura Stanicek , Noelia Lozano-Vidal, Diewertje Ilse Bink, Aukie Hooglugt, Wenjie Yao, Ilka Wittig, Jos van Rijssel, Jaap Diederik van Buul , Anke van Bergen, Alina Klems, Anne Sophie Ramms, Ferdinand Le Noble, Patrick Hofmann, Robert Szulcek, ShengPeng Wang, Stefan Offermanns, Meryem Seda Ercanoglu, Hyouk-Bum Kwon, Didier Stainier, Stephan Huveneers, Leo Kurian, Stefanie Dimmeler, Reinier Abraham Boon.<\/p>\n\n\n\n<p><em>Commun<\/em><em>&nbsp;Biol<\/em>., 2020 May 26;3(1):265. DOI: 10.1038\/s42003-020-0987-0<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/evboweb.files.wordpress.com\/2020\/07\/pub-high-june-20.jpg?w=600&amp;h=346\" alt=\"Pub High June 20\" class=\"wp-image-4907\"\/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Key findings<\/strong><\/h3>\n\n\n\n<ol class=\"wp-block-list\"><li>Fluid flow controls endothelial expression of several long non-coding RNAs (lncRNA), including the highly induced lncRNA LASSIE.<\/li><li>LASSIE is required for proper endothelial barrier function and for endothelial alignment in the direction of flow.<\/li><li>LASSIE physically interacts with adherens junction proteins and with the cytoskeletal protein nestin.<\/li><li>Loss of LASSIE results in weakening of the cytoskeletal attachment to adherens junctions.<\/li><\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Long non-coding RNA LASSIE regulates shear stress sensing and endothelial barrier function. Laura Stanicek , Noelia Lozano-Vidal, Diewertje Ilse Bink, Auki<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"give_campaign_id":0,"om_disable_all_campaigns":false,"pmpro_default_level":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_tribe_ticket_capacity":"0","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false,"footnotes":"","_tec_slr_enabled":"","_tec_slr_layout":""},"class_list":["post-720","page","type-page","status-publish","hentry","pmpro-has-access"],"aioseo_notices":[],"campaignId":"","ticketed":false,"_links":{"self":[{"href":"https:\/\/evbo.org\/index.php\/wp-json\/wp\/v2\/pages\/720","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/evbo.org\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/evbo.org\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/evbo.org\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/evbo.org\/index.php\/wp-json\/wp\/v2\/comments?post=720"}],"version-history":[{"count":2,"href":"https:\/\/evbo.org\/index.php\/wp-json\/wp\/v2\/pages\/720\/revisions"}],"predecessor-version":[{"id":739,"href":"https:\/\/evbo.org\/index.php\/wp-json\/wp\/v2\/pages\/720\/revisions\/739"}],"wp:attachment":[{"href":"https:\/\/evbo.org\/index.php\/wp-json\/wp\/v2\/media?parent=720"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}