{"id":713,"date":"2022-05-03T15:42:31","date_gmt":"2022-05-03T15:42:31","guid":{"rendered":"http:\/\/evbo.org\/?page_id=713"},"modified":"2022-05-03T15:56:53","modified_gmt":"2022-05-03T15:56:53","slug":"evbo-publication-highlights-august-2020","status":"publish","type":"page","link":"https:\/\/evbo.org\/index.php\/evbo-publication-highlights-august-2020\/","title":{"rendered":"EVBO publication highlights \u2013 August 2020 winner"},"content":{"rendered":"\n<p><strong>Trichoplein<\/strong><strong>&nbsp;binds PCM1 and controls endothelial cell function by regulating autophagy<\/strong><\/p>\n\n\n\n<p>Andrea Martello, Angela Lauriola, David Mellis, Elisa Parish, John C Dawson, Lisa Imrie, Martina Vidmar, Noor Gammoh, Tijana Miti\u0107, Mairi Brittan, Nicholas L Mills, Neil O Carragher, Domenico D\u2019Arca, Andrea Caporali.<\/p>\n\n\n\n<p><em>EMBO Rep.&nbsp;<\/em>2020 Jul 3;21(7):e48192. doi: 10.15252\/embr.201948192.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/evboweb.files.wordpress.com\/2020\/08\/evbo-publication-highlight-aug-2020.jpg?w=1024\" alt=\"\" class=\"wp-image-15155\"\/><\/figure>\n\n\n\n<p><strong>Key findings<\/strong><\/p>\n\n\n\n<p>1.The interaction of TCHP with PCM1 regulates basal autophagy through controlling GABARAP stability.<\/p>\n\n\n\n<p>2.Loss of TCHP results in impaired autophagy, the accumulation of SQSTM1\/p62 and endothelial dysfunction.<\/p>\n\n\n\n<p>3.Reduced TCHP and high SQSTM1\/p62 levels are detected in primary endothelial cells from patients with coronary artery disease.<\/p>\n\n\n\n<p>4.Accumulation of SQSTM1\/p62 correlates with impaired endothelial function and can be ameliorated by NF\u2010\u03baB inhibition.<\/p>\n\n\n\n<p><strong>Links to website\/social media<\/strong><\/p>\n\n\n\n<p><a href=\"https:\/\/www.ed.ac.uk\/profile\/andrea-caporali\">https:\/\/www.ed.ac.uk\/profile\/andrea-caporali<\/a><\/p>\n\n\n\n<p>&nbsp;Twitter: @EdiUniCIRR; @EdinUniCVS<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Trichoplein&nbsp;binds PCM1 and controls endothelial cell function by regulating autophagy Andrea Martello, Angela Lauriola, David Mellis, Elisa Parish, Jo<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"give_campaign_id":0,"om_disable_all_campaigns":false,"pmpro_default_level":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_tribe_ticket_capacity":"0","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false,"footnotes":"","_tec_slr_enabled":"","_tec_slr_layout":""},"class_list":["post-713","page","type-page","status-publish","hentry","pmpro-has-access"],"aioseo_notices":[],"campaignId":"","ticketed":false,"_links":{"self":[{"href":"https:\/\/evbo.org\/index.php\/wp-json\/wp\/v2\/pages\/713","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/evbo.org\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/evbo.org\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/evbo.org\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/evbo.org\/index.php\/wp-json\/wp\/v2\/comments?post=713"}],"version-history":[{"count":2,"href":"https:\/\/evbo.org\/index.php\/wp-json\/wp\/v2\/pages\/713\/revisions"}],"predecessor-version":[{"id":735,"href":"https:\/\/evbo.org\/index.php\/wp-json\/wp\/v2\/pages\/713\/revisions\/735"}],"wp:attachment":[{"href":"https:\/\/evbo.org\/index.php\/wp-json\/wp\/v2\/media?parent=713"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}