{"id":148,"date":"2024-01-05T10:53:06","date_gmt":"2024-01-05T10:53:06","guid":{"rendered":"http:\/\/evbo.org\/?page_id=148"},"modified":"2026-03-18T17:41:41","modified_gmt":"2026-03-18T17:41:41","slug":"paper-highlights","status":"publish","type":"page","link":"https:\/\/evbo.org\/index.php\/paper-highlights\/","title":{"rendered":"Publication Highlights"},"content":{"rendered":"\n<h1 class=\"wp-block-heading\">EVBO publication highlights<\/h1>\n\n\n\n<p><span style=\"text-decoration: underline;\">March 2026<\/span><\/p>\n\n\n\n<p><em>Deletion of Mfn2 in endothelial cells triggers a mitohormetic response that improves systemic metabolism and healthspan in mice<\/em><\/p>\n\n\n\n<p><a href=\"https:\/\/www.cell.com\/cell-metabolism\/fulltext\/S1550-4131(26)00012-4\">https:\/\/www.cell.com\/cell-metabolism\/fulltext\/S1550-4131(26)00012-4<\/a><\/p>\n\n\n\n<p>In this study\u00a0I\u00f1igo Chivite\u00a0and collaborators demonstrate that loss of endothelial Mfn2 induces a mitohormetic response that reprograms mitochondrial function and cellular metabolism. It shows that this adaptive signalling improves systemic glucose homeostasis and activates protective stress pathways, highlighting an active role for the endothelium in whole-body metabolic regulation. Finally, the study shows that targeting endothelial mitochondrial dynamics could represent a promising therapeutic strategy for metabolic diseases such as diabetes and obesity.<\/p>\n\n\n\n<p><span style=\"text-decoration: underline;\">February 2026<\/span><\/p>\n\n\n\n<p><em>Transcriptomics- and 3D imaging\u2013based characterization of the lymphatic vasculature in human skin<\/em>.<\/p>\n\n\n\n<p><a href=\"https:\/\/rupress.org\/jem\/article\/223\/1\/e20242353\/278441\/Transcriptomics-and-3D-imaging-based\">https:\/\/rupress.org\/jem\/article\/223\/1\/e20242353\/278441\/Transcriptomics-and-3D-imaging-based<\/a><\/p>\n\n\n\n<p>This study combines single-cell transcriptomics with 3D imaging to build the most detailed map to date of the human skin lymphatic vasculature. Aline Bauer and colleagues uncover previously unrecognized lymphatic endothelial cell subtypes, including specialized valve and mechanosensitive populations, and reveal important differences between human and mouse lymphatics. The work provides a new reference atlas for understanding lymphatic function in health and disease.<\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:100%\">\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\"><\/div><\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>EVBO publication highlights March 2026 Deletion of Mfn2 in endothelial cells triggers a mitohormetic response that improves systemic metabolism and healths<\/p>\n","protected":false},"author":1,"featured_media":2719,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"give_campaign_id":0,"om_disable_all_campaigns":false,"pmpro_default_level":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_tribe_ticket_capacity":"0","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false,"footnotes":"","_tec_slr_enabled":"","_tec_slr_layout":""},"class_list":["post-148","page","type-page","status-publish","has-post-thumbnail","hentry","pmpro-has-access"],"aioseo_notices":[],"campaignId":"","ticketed":false,"_links":{"self":[{"href":"https:\/\/evbo.org\/index.php\/wp-json\/wp\/v2\/pages\/148","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/evbo.org\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/evbo.org\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/evbo.org\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/evbo.org\/index.php\/wp-json\/wp\/v2\/comments?post=148"}],"version-history":[{"count":33,"href":"https:\/\/evbo.org\/index.php\/wp-json\/wp\/v2\/pages\/148\/revisions"}],"predecessor-version":[{"id":3278,"href":"https:\/\/evbo.org\/index.php\/wp-json\/wp\/v2\/pages\/148\/revisions\/3278"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/evbo.org\/index.php\/wp-json\/wp\/v2\/media\/2719"}],"wp:attachment":[{"href":"https:\/\/evbo.org\/index.php\/wp-json\/wp\/v2\/media?parent=148"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}