Blood vessel formation and maintenance are essential for development and tissue health. Endothelial cells in the vessel wall are connected by molecular junctions that safeguard vascular integrity. Recent discoveries show that mechanical tension at these junctions can generate protective signals, enabling blood vessels to adapt to changes in blood pressure. In vascular diseases such as hypertension and arterial stiffening, these connections weaken, leading to increased vessel permeability and leakage. In this postdoctoral project, you will investigate how endothelial cells sense and respond to changes in mechanical forces. You will use bioengineering approaches such as\u00a0optogenetic tools, substrate stretching\/stiffening\/flow platforms and 3D vessel\u2011on\u2011chip models\u00a0to precisely control mechanical cues, identify key molecules that regulate endothelial adhesion, and visualize their functional roles using advanced microscopy and quantitative analysis.<\/p>\n
Position: Postdoctoral researcher
\nDuration: 3 years
\nFunding: ZonMW Vici grant (PI: Dr. Stephan Huveneers)
\nIf you’re passionate about vascular biology, mechanobiology and cutting\u2011edge bioengineering and imaging techniques, we encourage you to apply.<\/p>\n","protected":false},"author":145,"featured_media":0,"template":"","meta":{"give_campaign_id":0,"om_disable_all_campaigns":false,"pmpro_default_level":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_tribe_ticket_capacity":"","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false,"_promoted":"","_job_location":"Amsterdam","_application":"https:\/\/werkenbij.amsterdamumc.org\/en\/vacatures\/research\/postdoc-vascular-biology","_company_name":"Amsterdam UMC","_company_website":"https:\/\/www.medicalbiochemistry.nl\/stephan-huveneers","_company_tagline":"","_company_twitter":"","_company_video":"","_filled":0,"_featured":0,"_remote_position":0,"_job_salary":"","_job_salary_currency":"","_job_salary_unit":""},"job-types":[27],"class_list":{"0":"post-3386","1":"job_listing","2":"type-job_listing","3":"status-publish","4":"hentry","5":"pmpro-has-access","7":"job-type-post-doctoral"},"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/evbo.org\/index.php\/wp-json\/wp\/v2\/job-listings\/3386","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/evbo.org\/index.php\/wp-json\/wp\/v2\/job-listings"}],"about":[{"href":"https:\/\/evbo.org\/index.php\/wp-json\/wp\/v2\/types\/job_listing"}],"author":[{"embeddable":true,"href":"https:\/\/evbo.org\/index.php\/wp-json\/wp\/v2\/users\/145"}],"wp:attachment":[{"href":"https:\/\/evbo.org\/index.php\/wp-json\/wp\/v2\/media?parent=3386"}],"wp:term":[{"taxonomy":"job_listing_type","embeddable":true,"href":"https:\/\/evbo.org\/index.php\/wp-json\/wp\/v2\/job-types?post=3386"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}