{"id":2185,"date":"2024-06-04T21:53:56","date_gmt":"2024-06-04T21:53:56","guid":{"rendered":"https:\/\/evbo.org\/?post_type=job_listing&p=2185"},"modified":"2024-08-05T00:22:28","modified_gmt":"2024-08-05T00:22:28","slug":"curie-institute-research-center-paris-27-mechanisms-of-flash-radiotherapy","status":"expired","type":"job_listing","link":"https:\/\/evbo.org\/?post_type=job_listing&p=2185","title":{"rendered":"Mechanisms of FLASH Radiotherapy"},"content":{"rendered":"

The hosting structure<\/strong>
\nThe Curie Institute Research Center
\nThe \u201cInstitut Curie\u201d is a major player in the research and fight against cancer. It consists of a hospital and a
\nResearch Center of more than 1000 employees with a strong international representativeness. The objective of the Curie Institute Research Center is to develop basic research and to use the knowledge produced to improve the diagnosis, prognosis, and therapeutics of cancers as part of the continuum between basic research and innovation serving the patient.<\/p>\n

Job description<\/strong>
\nLaboratory<\/strong>
\nThe \u201cRepair, Radiation, and Innovative Cancer Therapies\u201d team (U1021\/UMR3347\/Universit\u00e9 Paris
\nSaclay) specializes in developing new therapeutic strategies aimed at increasing the therapeutic index of
\nradiotherapy. One of the team\u2019s research focuses is understanding the molecular mechanisms of
\ntoxicities induced by radiotherapy, particularly how FLASH radiotherapy (Favaudon et al. Science
\nTranslational Medicine 2014) can reduce the development of pulmonary toxicities while maintaining
\nanti-tumor efficacy comparable to that of conventional radiotherapy (i.e., the FLASH effect). In close
\ncollaboration with clinicians (radiotherapists, pulmonologists, and thoracic surgeons) at the Institut
\nCurie and the Institut Mutualiste Montsouris, the team seeks to characterize, from patient samples, the
\ncellular and molecular effects of various innovative radiotherapy methods (e.g., FLASH radiotherapy)
\nusing molecular approaches (scRNAseq, spatial RNA profiling).<\/p>\n

Research Project<\/strong>
\nPreclinical studies in mice have identified several mechanistic pathways that might explain the FLASH
\neffect. Our current objective is to test these different mechanistic hypotheses using relevant cellular
\nmodels (e.g., organoids\/tumoroids, organotypic slices). Therefore, we are seeking a motivated researcher
\nto take charge of this project in collaboration with other team members. The selected candidate will have
\nrecently completed their PhD, with experience in the use of innovative cellular models and a quantitative
\napproach to biological processes. They will aim to: i) integrate into a dynamic, and supportive team, ii)
\naddress fundamental questions to accelerate the clinical transfer of new radiotherapy methods, iii) work
\nin an interdisciplinary environment integrating biologists, physicists, and clinicians<\/p>\n

Missions
\n\u2022 Establish and use innovative cellular models (e.g., organoids\/tumoroids, organotypic slices)
\nfrom patients\u2019 samples.
\n\u2022 Conduct single-cell RNA sequencing (scRNAseq) and spatial analyses (smFISH) experiments.
\n\u2022 Analyze sequencing data (RNAseq\/single-cell RNAseq) and microscopy images.
\nCandidate Profile
\nTraining and experience required
\n\u2022 PhD in cell biology
\n\u2022 Experience in developing innovative cellular models (e.g., organoids\/tumoroids)
\n\u2022 Expertise in microscopy and image analysis methods
\n\u2022 Knowledge of programming languages (Python, R)
\n\u2022 Proficiency in statistical analysis with R software
\nSkills
\n\u2022 Motivated and able to work independently
\n\u2022 Curious and proactive are key assets
\n\u2022 Essential team spirit
\n\u2022 Ability to communicate effectively with biologists and physicians
\nAll our opportunities are open to people with disabilities
\nContract information
\nType of contract: CDD
\nStarting date: July 2024
\nDuration: 18 months (with extension possibility)
\nWorking time: full time
\nRemuneration: according to the current grids
\nBenefits: Collective catering, reimbursement of transportation fees up to 70%, supplementary health
\ninsurance
\nLocation of the position: Orsay- near public transportation
\nContact
\nPlease send your CV, letter of motivation and 2 references, to job-ref-n7kzr8gpjh@emploi.beetween.com
\nDeadline for application: Monday 1st of July 2024<\/p>\n

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