EVBO Publication Highlight August 2020

Trichoplein binds PCM1 and controls endothelial cell function by regulating autophagy

Andrea Martello, Angela Lauriola, David Mellis, Elisa Parish, John C Dawson, Lisa Imrie, Martina Vidmar, Noor Gammoh, Tijana Mitić, Mairi Brittan, Nicholas L Mills, Neil O Carragher, Domenico D’Arca, Andrea Caporali.

EMBO Rep. 2020 Jul 3;21(7):e48192. doi: 10.15252/embr.201948192.

Key findings

1.The interaction of TCHP with PCM1 regulates basal autophagy through controlling GABARAP stability.

2.Loss of TCHP results in impaired autophagy, the accumulation of SQSTM1/p62 and endothelial dysfunction.

3.Reduced TCHP and high SQSTM1/p62 levels are detected in primary endothelial cells from patients with coronary artery disease.

4.Accumulation of SQSTM1/p62 correlates with impaired endothelial function and can be ameliorated by NF‐κB inhibition.

Links to website/social media

https://www.ed.ac.uk/profile/andrea-caporali

 Twitter: @EdiUniCIRR; @EdinUniCVS