Coronary Revascularization During Heart Regeneration Is Regulated by Epicardial and Endocardial Cues and Forms a Scaffold for Cardiomyocyte Repopulation.

Marín-Juez R, El-Sammak H, Helker CSM, Kamezaki A, Mullapudi ST, Bibli SI, Foglia MJ, Fleming I, Poss KD, Stainier DYR.
Developmental Cell, 2019 Nov 18;51(4):503-515.e4. DOI: 10.1016/j.devcel.2019.10.019

Key findings
1) Here we describe for the first time how coronary revascularization is regulated after cardiac injury in a model for cardiac regeneration.
2) The coordinated action of epicardium and endocardium allows different modes of coronary regeneration, forming a complex vascular scaffold.
3) Regenerated coronaries provide a scaffold available for cardiomyocyte repopulation, alterations in this scaffold impair cardiomyocyte regeneration.