Group leader (Associate professor)
Molecular Cell Biology Lab, Dept. Plasma Proteins
Sanquin Research and Landsteiner Laboratory, Academic Medical Center at the University of Amsterdam Street: Plesmanlaan 125
The Netherlands 1066CX
Education: 1992-1998; Medical Biology; University of Amsterdam, Amsterdam. Master of Science Degree: February 1998.
PhD thesis: March 14, 2004; “Signaling in leukocyte transendothelial migration”.
Dr. Jaap van Buul studied medical biology (specialization: Biochemistry and Molecular Biology) at the University of Amsterdam (UvA). From 1999 to 2004, he was a PhD student under supervision of Prof. Dr. Peter Hordijk at Sanquin Research and Landsteiner Laboratory. His work was focused on how leukocytes manage to migrate through the endothelial cell monolayer, with specific emphasis on the signalling routes that are activated in the endothelium, but also on the chemokine receptor distribution of leukocytes during migration. His thesis was awarded with the Sanquin PhD prize.
From June 2004 to September 2006, he received a “Ter Meulen” fellowship from the Royal Academy of Arts and Sciences (KNAW), which allowed him to do a post-doc at the lab of Prof. Dr. Keith Burridge at the department of Developmental and Cell Biology at the University of North Carolina in Chapel Hill, USA. During this time, he showed for the first time a functional role for the small Rho- GTPase RhoG. Additionally, he supervised 2 PhD students during this time. Several current fruitful collaborations stem from this period of time.
From October 2006, he received an E. Dekker fellowship and a VENI grant from NWO and started his independent research group at the department of Molecular Cell Biology at Sanquin Research, focused on the signalling proteins Rho-GEFs that control the activity of small GTPases during leukocyte transendothelial migration and endothelial integrity.
In 2009, he co-founded the Dutch Endothelial Biology Society (DEBS), a society that gives a platform to young investigators in the vascular biology field to present their work to a larger audience. Currently, he is the chair of the society. In 2009, his Dekker fellowship was extended and in 2010 he received an LSBR personal fellowship. This allowed him to extend his research line with in vitro flow models as well as in vivo animal models to study transendothelial migration and endothelial monolayer integrity. In addition to the research activities, he is regularly invited as a guest lecturer to several PhD- and Master student courses.
Currently, his lab continues to work on how endothelial cells control their integrity and respond to and collaborate with migrating leukocytes. Focus has been directed to real-time imaging of protein activity using FRET-based biosensors. In addition, in vivo intravital imaging of transmigration events using fluorescent reporter mice (e.g. lifeact-GFP, Dendra2) are initiated and combined with chronic inflammation disease models e.g. atherosclerosis and acute inflammation models, e.g. acute lung injury and ischemic reperfusion injury.
2011 Mar – present: Group leader (Permanent position); Dept. Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory, University of Amsterdam, the Netherlands.
2006 Oct – 2011 Feb: E. Dekker Research-fellow Netherlands Heart Foundation (Fixed-term). Dept. Molecular Cell Biology, Sanquin Research and Landsteiner Sanquin Research and Landsteiner Laboratory, University of Amsterdam, the Netherlands.
2004 Jul – 2006 Sept: Post-doctoral fellow in the lab of Prof. Dr. K. Burridge (Fixed-term). Department of Developmental and Cell Biology, Lineberger Comprehensive Cancer Center, UNC, Chapel Hill, NC, USA.
• President of the Dutch Society for Cell Biology (formally known as: NVvC). www.cell-biology.nl
• Chair and co-founder Dutch Endothelial Biology Society (DEBS). www.debsociety.nl
• Professional membership American Society for Cell Biology.
• Professional membership European Vascular Biology Organization.
• Professional membership North American Vascular Biology Organization.
In 2009, together with Dr. Reijerkerk, I founded the Dutch Endothelial Biology Society (DEBS; www.debsociety.nl). Our society has been very active in organizing scientific meetings and seminar series throughout the Netherlands. We have participated in joint meetings with other vascular-related societies like the Dutch Atherosclerosis Society (DAS), Internists Vascular Society (IVS) and the Microvascular and Vascular Biology Society (MIVAB). Internationally, we have organized joint meetings with the German microcirculation society. In all, we have a longstanding experience in and drive bringing together researchers from different interest groups but with all the same background interest, namely the vasculature.
This is exactly what I foresee as one of the biggest challenges for the EVBO: to bring together vascular biology research within the EU from all disciplines in order to organize ourselves and increase visibility, collaboration and eventually increase the success of grant applications. EVBO is the perfect platform to do so. Using functional and popular media such as the website and LinkedIn profiles, EVBO can start to launch itself as an indispensable visible factor of vascular biology within Europe.