Dr Beata Wojciak-Stothard

Job TitleBeata Wojciak Stothard (2)

Reader in Vascular Biology and Head of Vascular Therapeutics group

Address

Imperial College London, National Heart and Lung Institute, Hammersmith Campus. W120NN London, UK

Biography

Degrees and Diplomas

1986   MSc Cell Biology, Jagiellonian University, Cracow, Poland

1991   PhD in Cell Biology, Jagiellonian University, Cracow, Poland

Summary of previous posts: Following completion of her PhD, Dr Wojciak-Stothard held post-doctoral positions at both Glasgow University and University College London. Between 2000 and 2009, she carried out independent research at University College London funded by the British Heart Foundation, holding the positions of British Heart Foundation Intermediate Research Fellow, Senior Research Fellow, and Honorary Lecturer. In September 2009, Dr Wojciak-Stothard joined the Department of Experimental Medicine and Toxicology, Imperial College London and is now based in the state-of-the-art laboratories of the ICTEM Building on Imperial College’s Hammersmith Hospital Campus.

Recent relevant publications:

  1. Storck Saha E, Morales Sanfrutos J, Serwa R, et al., 2019, Dual chemical probes enable quantitative system-wide analysis of protein prenylation and prenylation dynamics, Nature Chemistry, Vol:11, ISSN:1755-4330, Pages:552-561
  1. Abdul-Salam V, Russomanno G, Chien-Nien C, et al., 2019, CLIC4/Arf6 pathway – a new lead in BMPRII inhibition in pulmonary hypertension, Circulation Research, Vol:124, ISSN:0009-7330, Pages:52-65
  1. Paulose Nadappuram B, Cadinu P, Barik A, et al., 2019, Nanoscale tweezers for single cell biopsies, Nature Nanotechnology, Vol:14, ISSN:1748-3387, Pages:80-88
  1. Duluc L, Ahmetaj-Shala B, Mitchell J, et al., 2017, Tipifarnib prevents development of hypoxia-induced pulmonary hypertension, Cardiovascular Research, Vol:113, ISSN:1755-3245, Pages:276-287
  1. Aldabbous L, Abdul-Salam V, McKinnon T, et al., 2016, Neutrophil Extracellular Traps Promote Angiogenesis: Evidence From Vascular Pathology in Pulmonary Hypertension., Arteriosclerosis Thrombosis and Vascular Biology, Vol:36, ISSN:1079-5642, Pages:2078-2087
  1. Belik D, Tsang H, Wharton J, et al., 2016, Endothelium-derived microparticles from chronically thromboembolic pulmonary hypertensive patients facilitate endothelial angiogenesis., Journal of Biomedical Science, Vol:23, ISSN:1423-0127
  1. Wojciak-Stothard B, Abdul-Salam VB, Lao KH, et al., 2014, Aberrant Chloride Intracellular Channel 4 Expression Contributes to Endothelial Dysfunction in Pulmonary Arterial Hypertension, Circulation, Vol:129, ISSN:0009-7322, Pages:1770-1780
  1. Wojciak-Stothard B, Zhao L, Oliver E, et al., 2012, Role of RhoB in the Regulation of Pulmonary Endothelial and Smooth Muscle Cell Responses to Hypoxia, Circulation Research, Vol:110, ISSN:0009-7330, Pages:1423-+

Research interests

The research focus of my group is to understand the mechanism of endothelial dysfunction in pulmonary arterial hypertension.  The objective of this work is to develop new therapeutic strategies for treatment of this severe disease. To achieve this we use data from proteomic, genomic and metabolomic screening of pulmonary hypertensive patients. This allows us to identify signalling mediators linked to endothelial dysfunction.

In particular, I am interested in endothelial responses to hypoxia and the role of Rho and Arf GTPases in the regulation of endothelial barrier function, proliferation and angiogenesis.  Targeting approaches involve modification of protein prenylation, design of new inhibitors of Ras family regulatory proteins, guanosine exchange factors (GEFs) and therapeutic delivery of exosomal microRNAs.

My current research focuses on establishing a model of a living, muscularised human lung blood vessel on a microchip.

Platform Statement

I am delighted to serve as a member of the EVBO Council. I have been a member of EVBO since its foundation and fully support EVBO idea of networking and scientific collaboration of vascular biologists in Europe.

I have extensive experience in attracting and managing grant funding, organization of national and international meetings, work in international grant review panels and supporting the careers of young scientists. I hope my experience will be of value to the Council and that I can assist in the growth and development of EVBO for the future. I would like to continue to serve EVBO as a member of the Medals Committee.

Web Address

http://www.imperial.ac.uk/people/b.wojciak-stothard